Trisomy of chromosome 15 in spontaneous leukemia of AKR mice.
نویسندگان
چکیده
Karyotypes of spontaneous thymomas of AKR mice were determined by trypsin-Giemsa banding methods. Trisomy of chromosome 15 occurred in 10 of 11 leukemic mice. Seven of the thymomas were predominantly trisomic for chromosome 15, one was trisomic for chromosome 12, and one exhibited multiple trisomies of chromosomes 3, 12, 15, and 17. Trisomy was not found in the norm-l AKR tissues examined.
منابع مشابه
An electron microscopic study of the leukemia virus in AKR and hybrid mice inoculated with ascites passage or tissue-cultured leukemic cells.
Various organs and tumors from AKR and hybrid mice and leukcmic cells grown in tissue culture were studied by electron microscopy. Only spleen and thymus were examined in fetuses and newborn mice. In adults, solid tumors, lymph nodes, and ascites cells were also studied. AKR mice dying of spontaneous leukemia showed typical virus particles (Types A and C) in their lymph nodes. No virus particle...
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ورودعنوان ژورنال:
- Proceedings of the National Academy of Sciences of the United States of America
دوره 72 4 شماره
صفحات -
تاریخ انتشار 1975